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A Guide to Sample Size for Animal-based Studies



AuthorPenny S. Reynolds

価格:12,540円 (本体 11,400円+税) 送料サービス

・Release: 2023

・ISBN: 9781119799979

・288 Pages

・Trim Size: 170 X 113 X 244 ・Paperback


A Guide to Sample Size for Animal-based Studies
Understand a foundational area of experimental design with this innovative reference

Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs − Replacement, Reduction and Refinement − the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable.

A Guide to Sample Size for Animal-based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to “rightsizing” animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results.

This book offers:

  • Step-by-step guidance in diverse methods for approximating and refining sample size
  • Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies
  • Sample size approximation methods for different types of data − binary, continuous, ordinal, time to event − and different study types − description, comparison, nested designs, reference interval construction and dose-response studies
  • Numerous worked examples, using real data from published papers, together with SAS and R code

A Guide to Sample Size for Animal-based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.

Table Of Contents

  • Preface vii
  • Acknowledgements viii
  • Part I. What is Sample Size?
  • The Sample Size Problem in Animal-Based Research 3
  • Sample Size Basics 9
  • Ten Strategies to Increase Information (and Reduce Sample Size) 17
  • Part II. Sample Size for Feasibility and Pilot Studies
  • Why Pilot Studies? 35
  • Operational Pilot Studies: ‘Can It Work?’ 47
  • Empirical and Translational Pilots 57
  • Feasibility Calculations: Arithmetic 81
  • Feasibility: Counting Subjects 89
  • Part III. Sample Size for Description
  • Descriptions and Summaries 103
  • Confidence Intervals and Precision 111
  • Prediction Intervals 127
  • Tolerance Intervals 133
  • Reference Intervals 143
  • Part IV. Sample Size for Comparison
  • Sample Size and Hypothesis Testing 155
  • A Bestiary of Effect Sizes 167
  • Comparing Two Groups: Continuous Outcomes 181
  • Comparing Two Groups: Proportions 189
  • Time-to-Event (Survival) Data 199
  • Comparing Multiple Factors 211
  • Hierarchical or Nested Data 233
  • Ordinal Data 249
  • Dose-Response Studies 257
  • Index 267