This issue of Veterinary Clinics: Small Animal Practice, edited by Dr. Annette Litster, is devoted to Small Animal Infectious Disease. Topics in this issue include: The dynamic nature of infectious disease risk in the 21st century: How dog transport impacts prevalence patterns; Dog transport and infectious disease risk: an international perspective; Effect of dog transport on high-risk infectious diseases (e.g. TVT, rabies etc.); H3N8 and H3N2; Feline panleukopenia: a re-emergent disease; Canine Lyme disease immunology; Canine leptospirosis diagnostics; Canine ehrlichiosis in the USA; Cutaneous and Renal Glomerular Vasculopathy (CRGV; Alabama Rot); Vector borne disease panel diagnostics; Feline vector-borne diseases; Canine brucellosis; and Current preventative strategies for rabies.